Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening

Autor Dandapani, Sivaraman, Rosse, Gerard, Southall, Noel, Salvino, Joseph M., Thomas, Craig J.
Vydáno v Curr Protoc Chem Biol (2012)

Identification of a new class of small molecules that efficiently reactivate latent Epstein-Barr virus

Autor Tikhmyanova, Nadezhda, Schultz, David C., Lee, Theresa, Salvino, Joseph M., Lieberman, Paul M.
Vydáno 2014

Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter

Autor Aggarwal, Shaili, Cheng, Mary Hongying, Salvino, Joseph M., Bahar, Ivet, Mortensen, Ole Valente
Vydáno v Biomedicines (2021)

Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer

Autor Salvino, Joseph M., Srikanth, Yellamelli V.V., Lou, Rongliang, Oyer, Halley M., Chen, Nan, Kim, Felix J.
Vydáno v Bioorg Med Chem Lett (2017)

Rapid optimization of the metabolic stability of an HIV-1 capsid inhibitor using a multistep computational workflow

Autor Meuser, Megan E., Reddy, Poli Adi Narayana, Dick, Alexej, Maurancy, Jean Marc, Salvino, Joseph M., Cocklin, Simon
Vydáno v J Med Chem (2021)

Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells

Autor Shen, Fei, Zhang, Yun, Jernigan, Danielle L., Feng, Xin, Yan, Jie, Garcia, Fernando U., Meucci, Olimpia, Salvino, Joseph M., Fatatis, Alessandro
Vydáno v Mol Cancer Res (2016)

Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation

Autor Tikhmyanova, Nadezhda, Tutton, Steve, Martin, Kayla A., Lu, Fang, Kossenkov, Andrew V., Paparoidamis, Nicholas, Kenney, Shannon, Salvino, Joseph M., Lieberman, Paul M.
Vydáno v PLoS Pathog (2017)

Development of a Novel Inducer for EBV Lytic Therapy

Autor Tikhmyanova, Nadezhda, Paparoidamis, Nicholas, Romero-Masters, James, Feng, Xin, Mohammed, Farheen Sultana, Reddy, Poli Adi Narayana, Kenney, Shannon C., Lieberman, Paul M., Salvino, Joseph M.
Vydáno v Bioorg Med Chem Lett (2019)

Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6

Autor Osko, Jeremy D., Porter, Nicholas J., Reddy, Poli Adi Narayana, Xiao, You-Cai, Rokka, Johanna, Jung, Manfred, Hooker, Jacob M., Salvino, Joseph M., Christianson, David W.
Vydáno v J Med Chem (2019)

BCL6 BTB-specific Inhibition via FX1 Treatment Reduces Tfh Cells & Reverses Lymphoid Follicle Hyperplasia in Indian Rhesus Macaque (Macaca mulatta)

Autor CAI, Yanhui, Watkins, Meagan A., Xue, Fengtian, Ai, Yong, Cheng, Huiming, Midkiff, Cecily C., Wang, Xiaolei, Alvarez, Xavier, Poli, Adi Narayana Reddy, Salvino, Joseph M., Veazey, Ronald S., Montaner, Luis J.
Vydáno v J Med Primatol (2019)

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer

Autor Thomas, Jeffrey D., Longen, Charles G., Oyer, Halley M., Chen, Nan, Maher, Christina M., Salvino, Joseph M., Kania, Blase, Anderson, Kelsey N., Ostrander, William F., Knudsen, Karen E., Kim, Felix J.
Vydáno v Cancer Res (2017)

Identification of a Novel Allosteric Modulator of the Human Dopamine Transporter

Autor Aggarwal, Shaili, Liu, Xiaonan, Rice, Caitlyn, Menell, Paul, Clark, Philip J., Paparoidamis, Nicholas, Xiao, You-cai, Salvino, Joseph M., Fontana, Andréia C. K., España, Rodrigo A., Kortagere, Sandhya, Mortensen, Ole V.
Vydáno v ACS Chem Neurosci (2019)

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-dependent SMAC Mediated Apoptotic Response in Non-Small Cell Lung Cancer

Autor Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, McNair, Christopher, Haber, Alex, Perepelyuk, Maryna, Bhardwaj, Anshul, Addya, Sankar, Ertel, Adam, Shoyele, Sunday, Birbe, Ruth, Salvino, Joseph M, Dicker, Adam P, Knudsen, Karen E, Den., Robert B
Vydáno v Clin Cancer Res (2018)

Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs

Autor De Dominici, Marco, Porazzi, Patrizia, Xiao, Youcai, Chao, Allen, Tang, Hsin-Yao, Kumar, Gaurav, Fortina, Paolo, Spinelli, Orietta, Rambaldi, Alessandro, Peterson, Luke F., Petruk, Svetlana, Barletta, Camilla, Mazo, Alexander, Cingolani, Gino, Salvino, Joseph M., Calabretta, Bruno
Vydáno v Blood (2020)

Targeting ACSS2 with a transition state mimetic inhibits triple negative breast cancer growth

Autor Miller, Katelyn D., Pniewski, Katherine, Perry, Caroline E., Papp, Sara B., Shaffer, Joshua D, Velasco-Silva, Jesse N., Casciano, Jessica C., Aramburu, Tomas M., Srikanth, Yellamelli V.V., Cassel, Joel, Skordalakes, Emmanuel, Kossenkov, Andrew V., Salvino, Joseph M., Schug, Zachary T.
Vydáno v Cancer Res (2021)

Metabolic control of BRISC-SHMT2 assembly regulates immune signaling

Autor Walden, Miriam, Tian, Lei, Ross, Rebecca, Sykora, Upasana M., Byrne, Dominic P., Hesketh, Emma L., Masandi, Safi K., Cassel, Joel, George, Rachel, Ault, James R., El Oualid, Farid, Pawłowski, Krzysztof, Salvino, Joseph M., Eyers, Patrick A., Ranson, Neil A., Del Galdo, Francesco, Greenberg, Roger A., Zeqiraj, Elton
Vydáno v Nature (2019)

A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors

Autor Barnoud, Thibaut, Leung, Jessica C., Leu, Julia I-Ju, Basu, Subhasree, Reddy Poli, Adi Narayana, D. Parris, Joshua L., Indeglia, Alexandra, Martynyuk, Tetyana, Good, Madeline, Gnanapradeepan, Keerthana, Sanseviero, Emilio, Moeller, Rebecca, Tang, Hsin-Yao, Cassel, Joel, Kossenkov, Andrew V., Liu, Qin, Speicher, David W., Gabrilovich, Dmitry I., Salvino, Joseph M., George, Donna L., Murphy, Maureen E.
Vydáno v Cancer Res (2020)