Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria

Por Leu, J. I-Ju, George, Donna L.
Publicado em 2007

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver

Por Leu, Julia I-Ju, Murphy, Maureen E, George, Donna L
Publicado em 2013

The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation

Por Zilfou, Jack T., Hoffman, William H., Sank, Michael, George, Donna L., Murphy, Maureen
Publicado em 2001

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70 (HSP70)

Por Leu, J. I-Ju, Pimkina, Julia, Frank, Amanda, Murphy, Maureen E., George, Donna L.
Publicado em 2009

Heat Shock Protein-70 Inhibition by the Small-Molecule 2-phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

Por Leu, J. I-Ju, Pimkina, Julia, Pandey, Pooja, Murphy, Maureen E., George, Donna L.
Publicado em 2011

Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate

Por Zhang, Pingfeng, Leu, Julia I-Ju, Murphy, Maureen E., George, Donna L., Marmorstein, Ronen
Publicado em 2014

Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket

Por Leu, Julia I-Ju, Zhang, Pingfeng, Murphy, Maureen E., Marmorstein, Ronen, George, Donna L.
Publicado no ACS Chem Biol (2014)

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a

Por Murphy, Maureen, Ahn, Jaimo, Walker, Kristen K., Hoffman, William H., Evans, Ronald M., Levine, Arnold J., George, Donna L.
Publicado em 1999

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

Por Leu, Julia I-Ju, Barnoud, Thibaut, Zhang, Gao, Tian, Tian, Wei, Zhi, Herlyn, Meenhard, Murphy, Maureen E., George, Donna L.
Publicado no Oncotarget (2017)

The P72R polymorphism of p53 predisposes to obesity and metabolic dysfunction

Por Kung, Che-Pei, Leu, Julia I-Ju, Basu, Subhasree, Khaku, Sakina, Anokye-Danso, Frederick, Liu, Qin, George, Donna L., Ahima, Rexford S., Murphy, Maureen E.
Publicado no Cell Rep (2016)

A modified HSP70 inhibitor shows broad activity as an anticancer agent

Por Balaburski, Gregor M., Leu, Julia I-Ju, Beeharry, Neil, Hayik, Seth, Andrake, Mark D., Zhang, Gao, Herlyn, Meenhard, Villanueva, Jessie, Dunbrack, Roland L., Yen, Tim, George, Donna L., Murphy, Maureen E.
Publicado em 2013

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

Por Jennis, Matthew, Kung, Che-Pei, Basu, Subhasree, Budina-Kolomets, Anna, Leu, Julia I-Ju, Khaku, Sakina, Scott, Jeremy P., Cai, Kathy Q., Campbell, Michelle R., Porter, Devin K., Wang, Xuting, Bell, Douglas A., Li, Xiaoxian, Garlick, David S., Liu, Qin, Hollstein, Monica, George, Donna L., Murphy, Maureen E.
Publicado no Genes Dev (2016)

HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors

Por Budina-Kolomets, Anna, Webster, Marie R., Leu, Julia I-Ju, Jennis, Matthew, Krepler, Clemens, Guerrini, Anastasia, Kossenkov, Andrew V., Xu, Wei, Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi K., Wu, Hong, Yin, Xiangfan, Liu, Qin, Lu, Yiling, Mills, Gordon B., Xu, Xiaowei, George, Donna L., Weeraratna, Ashani T., Murphy, Maureen E.
Publicado no Cancer Res (2016)