Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

Protein quality control is an important component of survival for all cells. The use of proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally exhibit greater levels of proteotoxic stress than do normal cells, and thus cancer cells tend to be more sensitive to prot...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Leu, Julia I-Ju, Barnoud, Thibaut, Zhang, Gao, Tian, Tian, Wei, Zhi, Herlyn, Meenhard, Murphy, Maureen E., George, Donna L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542216/
https://ncbi.nlm.nih.gov/pubmed/28484090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17321
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