A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors

The protein chaperone HSP70 is overexpressed in many cancers including colorectal cancer (CRC), where overexpression is associated with poor survival. We report here the creation of a uniquely acting HSP70 inhibitor that targets multiple compartments in the cancer cell including mitochondria. This i...

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Publicado no:Cancer Res
Main Authors: Barnoud, Thibaut, Leung, Jessica C., Leu, Julia I-Ju, Basu, Subhasree, Reddy Poli, Adi Narayana, D. Parris, Joshua L., Indeglia, Alexandra, Martynyuk, Tetyana, Good, Madeline, Gnanapradeepan, Keerthana, Sanseviero, Emilio, Moeller, Rebecca, Tang, Hsin-Yao, Cassel, Joel, Kossenkov, Andrew V., Liu, Qin, Speicher, David W., Gabrilovich, Dmitry I., Salvino, Joseph M., George, Donna L., Murphy, Maureen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718317/
https://ncbi.nlm.nih.gov/pubmed/33023943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0397
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