A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors

The protein chaperone HSP70 is overexpressed in many cancers including colorectal cancer (CRC), where overexpression is associated with poor survival. We report here the creation of a uniquely acting HSP70 inhibitor that targets multiple compartments in the cancer cell including mitochondria. This i...

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Opis bibliograficzny
Wydane w:Cancer Res
Główni autorzy: Barnoud, Thibaut, Leung, Jessica C., Leu, Julia I-Ju, Basu, Subhasree, Reddy Poli, Adi Narayana, D. Parris, Joshua L., Indeglia, Alexandra, Martynyuk, Tetyana, Good, Madeline, Gnanapradeepan, Keerthana, Sanseviero, Emilio, Moeller, Rebecca, Tang, Hsin-Yao, Cassel, Joel, Kossenkov, Andrew V., Liu, Qin, Speicher, David W., Gabrilovich, Dmitry I., Salvino, Joseph M., George, Donna L., Murphy, Maureen E.
Format: Artigo
Język:Inglês
Wydane: 2020
Hasła przedmiotowe:
Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718317/
https://ncbi.nlm.nih.gov/pubmed/33023943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0397
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