Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α

Mutant forms of p53 protein often possess protumorigenic functions, conferring increased survival and migration to tumor cells via their “gain-of-function” activity. Whether and how a common polymorphism in TP53 at amino acid 72 (Pro72Arg; referred to here as P72 and R72) impacts this gain of functi...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Basu, Subhasree, Gnanapradeepan, Keerthana, Barnoud, Thibaut, Kung, Che-Pei, Tavecchio, Michele, Scott, Jeremy, Watters, Andrea, Chen, Qing, Kossenkov, Andrew V., Murphy, Maureen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859965/
https://ncbi.nlm.nih.gov/pubmed/29463573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.309062.117
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