A Small Molecule Inhibitor of Inducible Heat Shock Protein 70 (HSP70)

The multifunctional, stress-inducible, molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70 expression is elevated in many cancers, contributing to tumor cell survival and resistance to therapy. We have determined that a small molecule ca...

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Bibliographic Details
Main Authors: Leu, J. I-Ju, Pimkina, Julia, Frank, Amanda, Murphy, Maureen E., George, Donna L.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771108/
https://ncbi.nlm.nih.gov/pubmed/19818706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.023
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