Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

Unique chemical methodology enables the synthesis of innovative and diverse scaffolds and chemotypes and allows access to previously unexplored “chemical space.” Compound collections based on such new synthetic methods can provide small-molecule probes of proteins and/or pathways whose functions are...

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Detalhes bibliográficos
Main Authors: Huryn, Donna M., Brodsky, Jeffrey L., Brummond, Kay M., Chambers, Peter G., Eyer, Benjamin, Ireland, Alex W., Kawasumi, Masaoki, LaPorte, Matthew G., Lloyd, Kayla, Manteau, Baptiste, Nghiem, Paul, Quade, Bettina, Seguin, Sandlin P., Wipf, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084104/
https://ncbi.nlm.nih.gov/pubmed/21502524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015251108
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