Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

Unique chemical methodology enables the synthesis of innovative and diverse scaffolds and chemotypes and allows access to previously unexplored “chemical space.” Compound collections based on such new synthetic methods can provide small-molecule probes of proteins and/or pathways whose functions are...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Huryn, Donna M., Brodsky, Jeffrey L., Brummond, Kay M., Chambers, Peter G., Eyer, Benjamin, Ireland, Alex W., Kawasumi, Masaoki, LaPorte, Matthew G., Lloyd, Kayla, Manteau, Baptiste, Nghiem, Paul, Quade, Bettina, Seguin, Sandlin P., Wipf, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2011
Aiheet:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084104/
https://ncbi.nlm.nih.gov/pubmed/21502524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015251108
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