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Chemical Induction of Hsp70 Reduces α-Synuclein Aggregation in Neuroglioma Cells

Misfolding and aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases including Parkinson's disease (PD). Analyses of post mortem tissues revealed the presence of molecular chaperones within α-syn aggregates, suggesting that chaperones pl...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Kilpatrick, Kiri, Novoa, Jose Andres, Hancock, Tommy, Guerriero, Christopher J., Wipf, Peter, Brodsky, Jeffrey L., Segatori, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532326/
https://ncbi.nlm.nih.gov/pubmed/23594135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400017h
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