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Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein

Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson’s disease (PD). The formation of α-syn aggregates results from aberrant accumulation of misfolded α-syn and insufficient or impaired activity of the two main intracell...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kilpatrick, Kiri, Zeng, Yimeng, Hancock, Tommy, Segatori, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366176/
https://ncbi.nlm.nih.gov/pubmed/25790376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120819
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