HSP90 inhibitor 17AAG attenuates sevoflurane-induced neurotoxicity in rats and human neuroglioma cells via induction of HSP70

BACKGROUND: 17AAG has been extensively studied for its antitumor effects that protect cells from lethal stress by maintaining protein stability. The role of 17AAG in sevoflurane-induced neuronal injury has never been studied. We aim to investigate the effect of 17AAG on sevoflurane-induced neurotoxi...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Liu, Min, Li, Moyun, Zhou, Yu, Zhou, Qian, Jiang, Yugang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158111/
https://ncbi.nlm.nih.gov/pubmed/32293462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02332-w
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