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Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation
17-(allylamino)-17-demethoxygeldanamycin (17AAG) is a benzoquinone ansamycin Hsp90 inhibitor which has promising anticancer activity in vitro, in animal models and in clinical trials. 17AAG has poor water-solubility which is a potential problem for clinical formulation. The hydroquinone derivative o...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580801/ https://ncbi.nlm.nih.gov/pubmed/18393300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21394 |
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