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Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation

17-(allylamino)-17-demethoxygeldanamycin (17AAG) is a benzoquinone ansamycin Hsp90 inhibitor which has promising anticancer activity in vitro, in animal models and in clinical trials. 17AAG has poor water-solubility which is a potential problem for clinical formulation. The hydroquinone derivative o...

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Detaylı Bibliyografya
Asıl Yazarlar: Guo, Wenchang, Siegel, David, Ross, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580801/
https://ncbi.nlm.nih.gov/pubmed/18393300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21394
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