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Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin Hsp90 inhibitors: Relevance for toxicity and mechanism of action
Two electron reduction of benzoquinone ansamycin (BA) Hsp90 inhibitors by NAD(P)H:Quinone Oxidoreductase 1 (NQO1) to hydroquinone ansamycins (BAH(2)) leads to greater Hsp90 inhibitory activity. BA can also be metabolized by one-electron reductases and can interact with glutathione, reactions which h...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574845/ https://ncbi.nlm.nih.gov/pubmed/18635747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022004 |
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