19-Substituted Benzoquinone Ansamycin Heat Shock Protein-90 Inhibitors: Biological Activity and Decreased Off-Target Toxicity

The benzoquinone ansamycins (BQAs) are a valuable class of antitumor agents that serve as inhibitors of heat shock protein (Hsp)-90. However, clinical use of BQAs has resulted in off-target toxicities, including concerns of hepatotoxicity. Mechanisms underlying the toxicity of quinones include their...

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Detalhes bibliográficos
Main Authors: Chang, Chuan-Hsin, Drechsel, Derek A., Kitson, Russell R. A., Siegel, David, You, Qiang, Backos, Donald S., Ju, Cynthia, Moody, Christopher J., Ross, David
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014664/
https://ncbi.nlm.nih.gov/pubmed/24682466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.090654
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