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Synthesis of Reblastatin, Autolytimycin, Non-Benzoquinone Analogs: Potent Inhibitors of Heat Shock Protein 90 (Hsp90)

A full account of an asymmetric synthesis of reblastatin (1), the first total synthesis of autolytimycin (2) and related structural compounds is described. The syntheses expand the utility of a highly regio-and diastereoselective hydrometalation aldehyde addition sequence to assemble the fully funct...

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Main Authors: Wrona, Iwona E., Gozman, Alexander, Taldone, Tony, Chiosis, Gabriela, Panek, James S.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906235/
https://ncbi.nlm.nih.gov/pubmed/20392070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo1000109
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