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Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

Hsp90 is an ATP dependent molecular chaperone protein which integrates multiple oncogenic pathways. As such, Hsp90 inhibition is a promising anti-cancer strategy. Several inhibitors that act on Hsp90 by binding to its N-terminal ATP pocket have entered clinical evaluation. Robust pre-clinical data s...

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Bibliografiske detaljer
Main Authors: Jhaveri, Komal, Taldone, Tony, Modi, Shanu, Chiosis, Gabriela
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288123/
https://ncbi.nlm.nih.gov/pubmed/22062686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2011.10.008
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