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Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
Hsp90 is an ATP dependent molecular chaperone protein which integrates multiple oncogenic pathways. As such, Hsp90 inhibition is a promising anti-cancer strategy. Several inhibitors that act on Hsp90 by binding to its N-terminal ATP pocket have entered clinical evaluation. Robust pre-clinical data s...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288123/ https://ncbi.nlm.nih.gov/pubmed/22062686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2011.10.008 |
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