Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

The benzoquinone ansamycin geldanamycin and its derivatives are inhibitors of heat shock protein Hsp90, an emerging target for novel therapeutic agents both in cancer and in neurodegeneration. However, toxicity of these compounds to normal cells has been ascribed to reaction with thiol nucleophiles...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Kitson, Russell R. A., Chang, Chuan-Hsin, Xiong, Rui, Williams, Huw E. L., Davis, Adrienne L., Lewis, William, Dehn, Donna L., Siegel, David, Roe, S. Mark, Prodromou, Chrisostomos, Ross, David, Moody, Christopher J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839848/
https://ncbi.nlm.nih.gov/pubmed/23511419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1596
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk