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Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90
The benzoquinone ansamycin geldanamycin and its derivatives are inhibitors of heat shock protein Hsp90, an emerging target for novel therapeutic agents both in cancer and in neurodegeneration. However, toxicity of these compounds to normal cells has been ascribed to reaction with thiol nucleophiles...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839848/ https://ncbi.nlm.nih.gov/pubmed/23511419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1596 |
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