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Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells

Glioblastoma multiforme (GBM) arises from genetic and signaling abnormalities in components of signal transduction pathways involved in proliferation, survival, and the cell cycle axis. Studies to date with single-agent targeted molecular therapy have revealed only modest effects in attenuating the...

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Detalhes bibliográficos
Main Authors: Sauvageot, Claire Marie-Elisabeth, Weatherbee, Jessica Leigh, Kesari, Santosh, Winters, Susan Elizabeth, Barnes, Jessica, Dellagatta, Jamie, Ramakrishna, Naren Raj, Stiles, Charles Dean, Kung, Andrew Li-Jen, Kieran, Mark W., Wen, Patrick Yung Chih
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718982/
https://ncbi.nlm.nih.gov/pubmed/18682579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-060
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