A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo

We tested the use of the small-molecule Inhibitor of Apoptosis Protein (IAP) inhibitor LBW242 in combination with the standard-of-care therapies of irradiation and temozolomide for malignant gliomas. In vitro assays demonstrated that LBW242 enhanced the cytotoxic activity of radiotherapy, and clonog...

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Detalhes bibliográficos
Main Authors: Ziegler, David S., Keating, Joanna, Kesari, Santosh, Fast, Eva M., Zawel, Leigh, Ramakrishna, Naren, Barnes, Jessica, Kieran, Mark W., Veldhuijzen van Zanten, Sophie E.M., Kung, Andrew L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145470/
https://ncbi.nlm.nih.gov/pubmed/21724651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor066
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