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Development of Peptidomimetics Targeting IAPs
Inhibitor of apoptosis proteins (IAPs) such as XIAP subvert apoptosis by binding and inhibiting caspases. Because occupation of the XIAP BIR3 peptide binding pocket by Smac abolishes the XIAP–caspase 9 interaction, it is a proapoptotic event of great therapeutic interest. An assay for pocket binding...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Kluwer Academic Publishers
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2710984/ https://ncbi.nlm.nih.gov/pubmed/19617919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10989-005-9003-2 |
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