Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells

Glioblastoma multiforme (GBM) arises from genetic and signaling abnormalities in components of signal transduction pathways involved in proliferation, survival, and the cell cycle axis. Studies to date with single-agent targeted molecular therapy have revealed only modest effects in attenuating the...

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Bibliographic Details
Main Authors: Sauvageot, Claire Marie-Elisabeth, Weatherbee, Jessica Leigh, Kesari, Santosh, Winters, Susan Elizabeth, Barnes, Jessica, Dellagatta, Jamie, Ramakrishna, Naren Raj, Stiles, Charles Dean, Kung, Andrew Li-Jen, Kieran, Mark W., Wen, Patrick Yung Chih
Format: Artigo
Language:Inglês
Published: Duke University Press 2009
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718982/
https://ncbi.nlm.nih.gov/pubmed/18682579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-060
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