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Hsp90 Chaperone Inhibitor 17-AAG Attenuates Aβ-Induced Synaptic Toxicity and Memory Impairment

The excessive accumulation of soluble amyloid peptides (Aβ) plays a crucial role in the pathogenesis of Alzheimer's disease (AD), particularly in synaptic dysfunction. The role of the two major chaperone proteins, Hsp70 and Hsp90, in clearing misfolded protein aggregates has been established. D...

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書目詳細資料
Main Authors:	Chen, Yaomin, Wang, Bin, Liu, Dan, Li, Jing Jing, Xue, Yueqiang, Sakata, Kazuko, Zhu, Ling-qiang, Heldt, Scott A., Xu, Huaxi, Liao, Francesca-Fang
格式:	Artigo
語言:	Inglês
出版:	Society for Neuroscience 2014
主題:	Brief Communications
在線閱讀:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3921421/ https://ncbi.nlm.nih.gov/pubmed/24523537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0151-13.2014
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Hsp90 Chaperone Inhibitor 17-AAG Attenuates Aβ-Induced Synaptic Toxicity and Memory Impairment

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