Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

Unique chemical methodology enables the synthesis of innovative and diverse scaffolds and chemotypes and allows access to previously unexplored “chemical space.” Compound collections based on such new synthetic methods can provide small-molecule probes of proteins and/or pathways whose functions are...

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Главные авторы: Huryn, Donna M., Brodsky, Jeffrey L., Brummond, Kay M., Chambers, Peter G., Eyer, Benjamin, Ireland, Alex W., Kawasumi, Masaoki, LaPorte, Matthew G., Lloyd, Kayla, Manteau, Baptiste, Nghiem, Paul, Quade, Bettina, Seguin, Sandlin P., Wipf, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084104/
https://ncbi.nlm.nih.gov/pubmed/21502524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015251108
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