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The P72R polymorphism of p53 predisposes to obesity and metabolic dysfunction
p53 is well known for its tumor suppressor role, but this protein also has a poorly understood role in the regulation of metabolism. Human studies have implicated a common polymorphism at codon 72 of p53 in diabetic and pre-diabetic phenotypes. To understand this role, we utilized a humanized mouse...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4926645/ https://ncbi.nlm.nih.gov/pubmed/26947067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.037 |
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