HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors

The stress-inducible chaperone protein HSP70 (HSPA1) is implicated in melanoma development and HSP70 inhibitors exert tumor-specific cytotoxic activity in cancer. In this study, we documented that a significant proportion of melanoma tumors express high levels of HSP70, particularly at advanced stag...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Budina-Kolomets, Anna, Webster, Marie R., Leu, Julia I-Ju, Jennis, Matthew, Krepler, Clemens, Guerrini, Anastasia, Kossenkov, Andrew V., Xu, Wei, Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi K., Wu, Hong, Yin, Xiangfan, Liu, Qin, Lu, Yiling, Mills, Gordon B., Xu, Xiaowei, George, Donna L., Weeraratna, Ashani T., Murphy, Maureen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939897/
https://ncbi.nlm.nih.gov/pubmed/26984758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2137
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