miR-200c/Bmi1 axis and epithelial–mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment

Resistance to BRAF inhibitors (BRAFi) is one of the major challenges for targeted therapies for BRAF-mutant melanomas. However, little is known about the role of microRNAs in conferring BRAFi resistance. Herein, we demonstrate that miR-200c expression is significantly reduced whereas miR-200c target...

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Bibliografiske detaljer
Udgivet i:Pigment Cell Melanoma Res
Main Authors: Liu, Shujing, Tetzlaff, Michael T., Wang, Tao, Yang, Ruifeng, Xie, Lin, Zhang, Gao, Krepler, Clemens, Xiao, Min, Beqiri, Marilda, Xu, Wei, Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi K., Xu, Weiting, Wei, Zhi, Herlyn, Meenhard, Yao, Yuan, Zhang, Litao, Wang, Yingjie, Zhang, Lin, Xu, Xiaowei
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597606/
https://ncbi.nlm.nih.gov/pubmed/25903073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12379
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