ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma

Resistance to BRAF and MEK inhibitor (BRAFi+MEKi) in BRAF mutant tumors occurs through heterogeneous mechanisms, including ERK reactivation and autophagy. Little is known about the mechanisms by which ERK reactivation, or autophagy are induced by BRAFi+MEKi. Here we report that in BRAF mutant melano...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Ojha, Rani, Leli, Nektaria M., Onorati, Angelique, Piao, Shengfu, Verginadis, Ioannis. I., Tameire, Feven, Rebecca, Vito W., Chude, Cynthia I., Murugan, Sengottuvelan, Fennelly, Colin, Noguera-Ortega, Estela, Liu, Shujing, Xu, Xiaowei, Krepler, Clemens, Xiao, Min, Xu, Wei, Wei, Zhi, Frederick, Dennie T., Boland, Genevieve, Mitchell, Tara C., Karakousis, Giorgos C., Schuchter, Lynn M., Flaherty, Keith T., Zhang, Gao, Herlyn, Meenhard, Koumenis, Constantinos, Amaravadi, Ravi K.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397701/
https://ncbi.nlm.nih.gov/pubmed/30563872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0348
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