ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression

The c-Myc oncogene (MYC) drives malignant progression, but also induces robust anabolic and proliferative programs leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. We have uncovered an essential role for the transcription factor ATF4 in...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Tameire, Feven, Verginadis, Ioannis I., Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S., Ojha, Rani, Salas, Carlo, Chinga, Frank, Monroy, Alexandra. M., Fu, Weixuan, Wang, Paul, Kossenkov, Andrew, Ye, Jiangbin, Amaravadi, Ravi K., Ignatova, Zoya, Fuchs, Serge Y., Diehl, J. Alan, Ruggero, Davide, Koumenis, Constantinos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608727/
https://ncbi.nlm.nih.gov/pubmed/31263264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0347-9
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