The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

The transcription factor ATF4 regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses, and it is overexpressed in human solid tumours, suggesting that it has an important function in tumour progression. Here, we report that inhibition of ATF4 ex...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Ye, Jiangbin, Kumanova, Monika, Hart, Lori S, Sloane, Kelly, Zhang, Haiyan, De Panis, Diego N, Bobrovnikova-Marjon, Ekaterina, Diehl, J Alan, Ron, David, Koumenis, Constantinos
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2010
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892366/
https://ncbi.nlm.nih.gov/pubmed/20473272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.81
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia