Amino Acid Deprivation Promotes Tumor Angiogenesis through the GCN2/ATF4 Pathway

As tumors continue to grow and exceed their blood supply, nutrients become limited leading to deficiencies in amino acids (AAD), glucose (GD), and oxygen (hypoxia). These alterations result in significant changes in gene expression. While tumors have been shown to overcome the stress associated with...

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Detalhes bibliográficos
Main Authors: Wang, Yugang, Ning, Yu, Alam, Goleeta N, Jankowski, Brandon M, Dong, Zhihong, Nör, Jacques E, Polverini, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730049/
https://ncbi.nlm.nih.gov/pubmed/23908598
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