Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H(2)S production

Angiogenesis, the formation of new blood vessels by endothelial cells (EC), is an adaptive response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor (VEGF) upon ischemia or exercise. Hypoxia is the best-understood trigger of VEGF expression via the transcription fact...

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Publicado no:Cell
Main Authors: Longchamp, Alban, Mirabella, Teodelinda, Arduini, Alessandro, MacArthur, Michael R., Das, Abhirup, Treviño-Villarreal, J. Humberto, Hine, Christopher, Ben-Sahra, Issam, Knudsen, Nelson H., Brace, Lear E., Reynolds, Justin, Mejia, Pedro, Tao, Ming, Sharma, Gaurav, Wang, Rui, Corpataux, Jean-Marc, Haefliger, Jacques-Antoine, Ahn, Kyo Han, Lee, Chih-Hao, Manning, Brendan D., Sinclair, David A., Chen, Christopher S., Ozaki, C. Keith, Mitchell, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901681/
https://ncbi.nlm.nih.gov/pubmed/29570992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.001
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