HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors

The stress-inducible chaperone protein HSP70 (HSPA1) is implicated in melanoma development and HSP70 inhibitors exert tumor-specific cytotoxic activity in cancer. In this study, we documented that a significant proportion of melanoma tumors express high levels of HSP70, particularly at advanced stag...

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Vydáno v:Cancer Res
Hlavní autoři: Budina-Kolomets, Anna, Webster, Marie R., Leu, Julia I-Ju, Jennis, Matthew, Krepler, Clemens, Guerrini, Anastasia, Kossenkov, Andrew V., Xu, Wei, Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi K., Wu, Hong, Yin, Xiangfan, Liu, Qin, Lu, Yiling, Mills, Gordon B., Xu, Xiaowei, George, Donna L., Weeraratna, Ashani T., Murphy, Maureen E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939897/
https://ncbi.nlm.nih.gov/pubmed/26984758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2137
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