Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6

Inhibition of histone deacetylase 6 (HDAC6) has emerged as a promising therapeutic strategy for the treatment of cancer, chemotherapy-induced peripheral neuropathy, and neurodegenerative disease. The recent X-ray crystal structure determination of HDAC6 enables an understanding of structural feature...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Osko, Jeremy D., Porter, Nicholas J., Reddy, Poli Adi Narayana, Xiao, You-Cai, Rokka, Johanna, Jung, Manfred, Hooker, Jacob M., Salvino, Joseph M., Christianson, David W.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952581/
https://ncbi.nlm.nih.gov/pubmed/31793776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01540
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