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Structural Determinants of Affinity and Selectivity in the Binding of Inhibitors to Histone Deacetylase 6
Histone deacetylase 6 (HDAC6) is associated with multiple neurological disorders as well as aggressive cancers, making its selective inhibition highly desirable for therapeutic purposes. The basic molecular design of an effective HDAC6 inhibitor consists of a zinc-binding group, a linker, and a capp...
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| Published in: | Bioorg Med Chem Lett |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7067655/ https://ncbi.nlm.nih.gov/pubmed/32067866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127023 |
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