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Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6

The zinc hydrolase histone deacetylase 6 (HDAC6) is unique among vertebrate deacetylases in that it contains two catalytic domains, designated CD1 and CD2. Both domains are fully functional as lysine deacetylases in vitro. However, the in vivo function of only the CD2 domain is well defined, whereas...

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Pubblicato in:Acta Crystallogr F Struct Biol Commun
Autori principali: Osko, Jeremy D., Christianson, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470039/
https://ncbi.nlm.nih.gov/pubmed/32880591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X20010250
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