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Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6
Among the metal-dependent histone deacetylases, the class IIb isozyme HDAC6 is remarkable due to its role in the regulation of microtubule dynamics in the cytosol. Selective inhibition of HDAC6 results in microtubule hyperacetylation, leading to cell cycle arrest and apoptosis, which is a validated...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6030506/ https://ncbi.nlm.nih.gov/pubmed/29775292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00367 |
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