Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 (HDAC6) Inhibitors

The phenothiazine system was identified as a favorable cap group for potent and selective histone deacetylase 6 (HDAC6) inhibitors. Here we report the preparation and systematic variation of phenothiazines and analogues containing a benzhydroxamic acid moiety as zinc-binding group. We evaluated thei...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Vögerl, Katharina, Ong, Nghia, Senger, Johanna, Herp, Daniel, Schmidtkunz, Karin, Marek, Martin, Müller, Martin, Bartel, Karin, Shaik, Tajith B., Porter, Nicholas J., Robaa, Dina, Christianson, David W., Romier, Christophe, Sippl, Wolfgang, Jung, Manfred, Bracher, Franz
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519732/
https://ncbi.nlm.nih.gov/pubmed/30645113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01090
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