Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition

[Image: see text] To cope with hypoxia, tumor cells have developed a number of adaptive mechanisms mediated by hypoxia-inducible factor 1 (HIF-1) to promote angiogenesis and cell survival. Due to significant roles of HIF-1 in the initiation, progression, metastasis, and resistance to treatment of mo...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Kwon, Do-Yeon, Lee, Hye Eun, Weitzel, Douglas H., Park, Kyunghye, Lee, Sun Hee, Lee, Chen-Ting, Stephenson, Tesia N., Park, Hyeri, Fitzgerald, Michael C., Chi, Jen-Tsan, Mook, Robert A., Dewhirst, Mark W., Lee, You Mie, Hong, Jiyong
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765894/
https://ncbi.nlm.nih.gov/pubmed/26394152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01220
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