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Synthetic efforts towards the stereoselective synthesis of NF00659B(1)
NF00659B(1) is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B(1) is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strate...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6098985/ https://ncbi.nlm.nih.gov/pubmed/29503022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.02.038 |
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