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Discovery of Manassantin A Protein Targets using Large-Scale Protein Folding and Stability Measurements

Manassantin A is a natural product that has been shown to have anticancer activity in cell-based assays, but has a largely unknown mode-of-action. Described here is the use of two different energetics-based approaches to identify protein targets of manassantin A. Using the Stability of Proteins from...

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Detalhes bibliográficos
Publicado no:J Proteome Res
Main Authors: Geer Wallace, M. Ariel, Kwon, Do-Yeon, Weitzel, Douglas H., Lee, Chen-Ting, Stephenson, Tesia N., Chi, Jen-Tsan, Mook, Robert A., Dewhirst, Mark W., Hong, Jiyong, Fitzgerald, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270646/
https://ncbi.nlm.nih.gov/pubmed/27322910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.6b00237
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