Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophen...

Por Vallone, Alessandra, D’Alessandro, Sarah, Brogi, Simone, Brindisi, Margherita, Chemi, Giulia, Alfano, Gloria, Lamponi, Stefania, Lee, Soon Goo, Jez, Joseph M., Koolen, Karin J.M., Dechering, Koen J., Saponara, Simona, Fusi, Fabio, Gorelli, Beatrice, Taramelli, Donatella, Parapini, Silvia, Caldelari, Reto, Campiani, Giuseppe, Gemma, Sandra, Butini, Stefania
Publicado no Eur J Med Chem (2018)

Design, Synthesis and Biological Evaluation of WC-9 Analogues as Antiparasitic Agents

Por Elicio, Pablo D., Chao, María N., Galizzi, Melina, Li, Catherine, Szajnman, Sergio H., Docampo, Roberto, Moreno, Silvia N. J., Rodriguez, Juan B.
Publicado em 2013

Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity

Por Chorell, Erik, Bengtsson, Christoffer, Banchelin, Thomas Sainte-Luce, Das, Pralay, Uvell, Hanna, Sinha, Arun K., Pinkner, Jerome S., Hultgren, Scott J., Almqvist, Fredrik
Publicado em 2011

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca(2+)/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain

Por Kaur, Jatinder, Soto-Velasquez, Monica, Ding, Zhong, Ghanbarpour, Ahmadreza, Lill, Markus A., van Rijn, Richard M., Watts, Val J., Flaherty, Daniel P.
Publicado no Eur J Med Chem (2018)

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

Por Amblard, Franck, Fromentin, Emilie, Detorio, Mervi, Obikhod, Alexander, Rapp, Kimberly L., McBrayer, Tamara R., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Publicado em 2009

5-Aminothiophene-2,4-dicarboxamide Analogues as Hepatitis B Virus Capsid Assembly Effectors

Por Tang, Jing, Huber, Andrew D., Pineda, Dallas L., Boschert, Kelsey N., Wolf, Jennifer J., Kankanala, Jayakanth, Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Publicado no Eur J Med Chem (2018)

Small lipidated anti-obesity compounds derived from neuromedin U

Por Micewicz, Ewa D., Bahattab, Omar S.O., Willars, Gary B., Waring, Alan J., Navab, Mohamad, Whitelegge, Julian P., McBride, William H., Ruchala, Piotr
Publicado no Eur J Med Chem (2015)

Evaluation of 2-Thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA Activators

Por Marugan, Juan J., Zheng, Wei, Motabar, Omid, Southall, Noel, Goldin, Ehud, Sidransky, Ellen, Aungst, Ronald A., Liu, Ke, Sadhukhan, Subir Kumar, Austin, Christopher P.
Publicado em 2010

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

Por Wang, Lei, Tang, Jing, Huber, Andrew, Casey, Mary, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Publicado no Eur J Med Chem (2018)

Novel Selective Thiadiazine DYRK1A Inhibitor Lead Scaffold with Human Pancreatic β-cell Proliferation Activity

Por Kumar, Kunal, Man-Un Ung, Peter, Wang, Peng, Wang, Hui, Li, Hailing, Andrews, Mary K., Stewart, Andrew F., Schlessinger, Avner, DeVita, Robert J.
Publicado no Eur J Med Chem (2018)

Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors

Por Jarończyk, Małgorzata, Wołosewicz, Karol, Gabrielsen, Mari, Nowak, Gabriel, Kufareva, Irina, Mazurek, Aleksander P., Ravna, Aina W., Abagyan, Ruben, Bojarski, Andrzej J., Sylte, Ingebrigt, Chilmonczyk, Zdzisław
Publicado em 2012

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D

Por Zogota, Rimants, Kinena, Linda, Withers-Martinez, Chrislaine, Blackman, Michael J., Bobrovs, Raitis, Pantelejevs, Teodors, Kanepe-Lapsa, Iveta, Ozola, Vita, Jaudzems, Kristaps, Suna, Edgars, Jirgensons, Aigars
Publicado no Eur J Med Chem (2019)

Design, Synthesis and Biological Evaluation of Sulfur-Containing 1,1-Bisphosphonic Acids as Antiparasitic Agents

Por Recher, Marion, Barboza, Alejandro P., Li, Zhu-Hong, Galizzi, Melina, Ferrer-Casal, Mariana, Szajnman, Sergio H., Docampo, Roberto, Moreno, Silvia N. J., Rodriguez, Juan B.
Publicado em 2012

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: tolerance of a nonflexible linker

Por Tang, Jing, Do, Ha T., Huber, Andrew D., Casey, Mary C., Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Publicado no Eur J Med Chem (2019)

Synthesis, Antimicrobial Activity, Attenuation of Aminoglycoside Resistance in MRSA, and Ribosomal A-site Binding of Pyrene-Neomycin Conjugates

Por Story, Sandra, Skriba, Michael J., Maiti, Krishnagopal, Ranjan, Nihar, Degtyareva, Natalya N., Green, Keith D., Khodaverdian, Verjine, Oyelere, Adegboyega K., Garneau-Tsodikova, Sylvie, Arya, Dev P.
Publicado no Eur J Med Chem (2018)

Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogues for boron neutron capture therapy of cancer

Por Agarwal, Hitesh K., Khalil, Ahmed, Ishita, Keisuke, Yang, Weilian, Nakkula, Robin J., Wu, Lai-Chu, Ali, Tehane, Tiwari, Rohit, Byun, Youngjoo, Barth, Rolf F., Tjarks, Werner
Publicado no Eur J Med Chem (2015)

New Highly Active Antiplatelet Agents with Dual Specificity for Platelet P2Y(1) and P2Y(12) Adenosine Diphosphate Receptors

Por Yanachkov, Ivan B., Chang, Hung, Yanachkova, Milka I., Dix, Edward J., Berny-Lang, Michelle A., Gremmel, Thomas, Michelson, Alan D., Wright, George E., Frelinger, Andrew L.
Publicado no Eur J Med Chem (2015)

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

Por Wang, Lei, Tang, Jing, Huber, Andrew, Casey, Mary, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Xie, Jiashu, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Publicado no Eur J Med Chem (2018)

Development of Potent and Selective Plasmodium falciparum Calcium-Dependent Protein Kinase 4 (PfCDPK4) Inhibitors that Block the Transmission of Malaria to Mosquitoes

Por Vidadala, Rama Subba Rao, Ojo, Kayode K., Johnson, Steven M., Zhang, Zhongsheng, Leonard, Stephen E., Mitra, Arinjay, Choi, Ryan, Reid, Molly C., Keyloun, Katelyn R., Fox, Anna M.W., Kennedy, Mark, Silver-Brace, Tiffany, Hume, Jen C. C., Kappe, Stefan, Verlinde, Christophe L.M.J., Fan, Erkang, Merritt, Ethan A., Van Voorhis, Wesley C., Maly, Dustin J.
Publicado em 2014

The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methy...

Por Pati, Hari N., Das, Umashankar, Das, Swagatika, Bandy, Brian, De Clercq, Erik, Balzarini, Jan, Kawase, Masami, Sakagami, Hiroshi, Quail, J. Wilson, Stables, James P., Dimmock, Jonathan R.
Publicado em 2008