The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones

This study demonstrated that replacement of the axial protons on the C2 and C6 atoms of various 1-methyl-3,5-bis(benzylidene)-4-piperidones 3 by a dimethylene bridge leading to series 2 lowered cytotoxic potencies. Four compounds 2a and 3a–c emerged as lead molecules based on their toxicity towards...

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Autors principals: Pati, Hari N., Das, Umashankar, Das, Swagatika, Bandy, Brian, De Clercq, Erik, Balzarini, Jan, Kawase, Masami, Sakagami, Hiroshi, Quail, J. Wilson, Stables, James P., Dimmock, Jonathan R.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276583/
https://ncbi.nlm.nih.gov/pubmed/18468733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2008.03.015
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