Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors

It is well known that 6-nitroquipazine exhibits about 150-fold higher affinity for the serotonin transporter (SERT) than quipazine and recently we showed quipazine buspirone analogues with high to moderate SERT affinity. Now we have designed and synthesized several 6-nitroquipazine buspirone derivat...

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Detalhes bibliográficos
Main Authors: Jarończyk, Małgorzata, Wołosewicz, Karol, Gabrielsen, Mari, Nowak, Gabriel, Kufareva, Irina, Mazurek, Aleksander P., Ravna, Aina W., Abagyan, Ruben, Bojarski, Andrzej J., Sylte, Ingebrigt, Chilmonczyk, Zdzisław
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365592/
https://ncbi.nlm.nih.gov/pubmed/22309909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.01.012
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