6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains an unvalidated drug target. Reported HIV RNase H inhibitors generally lack significant antiviral activity. We report herein the design, synthesis, biochemical and antiviral evaluations of a new...

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Publicado no:Eur J Med Chem
Main Authors: Wang, Lei, Tang, Jing, Huber, Andrew, Casey, Mary, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114935/
https://ncbi.nlm.nih.gov/pubmed/30031978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.07.035
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