3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides potently inhibit HIV-1 integrase and RNase H

Resistance selection by human immunodeficiency virus (HIV) towards known drug regimens necessitates the discovery of structurally novel antivirals with a distinct resistance profile. Based on our previously reported 3-hydroxypyrimidine-2,4-dione (HPD) core we have designed and synthesized a new inte...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Wu, Bulan, Tang, Jing, Wilson, Daniel J., Huber, Andrew D., Casey, Mary C., Ji, Juan, Kankanala, Jayakanth, Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945466/
https://ncbi.nlm.nih.gov/pubmed/27283261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00040
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