Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function yet to be exploited as an antiviral target. One of the possible challenges may be that targeting HIV RNase H is confronted with a steep substrate barr...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Vernekar, Sanjeev Kumar V., Tang, Jing, Wu, Bulan, Huber, Andrew D., Casey, Mary C., Myshakina, Nataliya, Wilson, Daniel, Kankanala, Jayakanth, Kirby, Karen A., Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526604/
https://ncbi.nlm.nih.gov/pubmed/28525279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00440
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