Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

[Image: see text] Reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not targeted by current chemotherapy against human immunodeficiency virus (HIV). Although numerous chemotypes have been reported to inhibit HIV RNase H biochemically,...

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Vydáno v:J Med Chem
Hlavní autoři: Vernekar, Sanjeev Kumar V., Liu, Zheng, Nagy, Eva, Miller, Lena, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Sarafianos, Stefan G., Parniak, Michael A., Wang, Zhengqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306517/
https://ncbi.nlm.nih.gov/pubmed/25522204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501132s
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