6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not targeted by current drugs. Although a few chemotypes have been reported to inhibit HIV RNase H in biochemical assays, their general lack of signif...

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Publicado en:Eur J Med Chem
Main Authors: Wang, Lei, Tang, Jing, Huber, Andrew, Casey, Mary, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Xie, Jiashu, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112573/
https://ncbi.nlm.nih.gov/pubmed/30031976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.07.039
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