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Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function yet to be exploited as an antiviral target. One of the possible challenges may be that targeting HIV RNase H is confronted with a steep substrate barr...

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Pubblicato in:J Med Chem
Autori principali: Vernekar, Sanjeev Kumar V., Tang, Jing, Wu, Bulan, Huber, Andrew D., Casey, Mary C., Myshakina, Nataliya, Wilson, Daniel, Kankanala, Jayakanth, Kirby, Karen A., Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526604/
https://ncbi.nlm.nih.gov/pubmed/28525279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00440
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