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Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function yet to be exploited as an antiviral target. One of the possible challenges may be that targeting HIV RNase H is confronted with a steep substrate barr...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Vernekar, Sanjeev Kumar V., Tang, Jing, Wu, Bulan, Huber, Andrew D., Casey, Mary C., Myshakina, Nataliya, Wilson, Daniel, Kankanala, Jayakanth, Kirby, Karen A., Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526604/
https://ncbi.nlm.nih.gov/pubmed/28525279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00440
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